general info on a new science of an age-reverse to youth and nootropics
thought to share a summary of the science of combining two supplements for age-reverse and nootropics that has emerged the past year. you can search for “Nicotinamide Riboside” and “Pterostilbene” to find a plethora of science based articles. i will be testing both soon.
here is a general introduction to NAD+,
and a general science intro,
typically compared to resveratrol, for oral ingestion resveratrol has a 20% bioavailability whereas pterostilbene is near 80% at doses of 56-168mg/kg.
TRU Niagen is made by ChromaDex and is FDA approved is a well reviewed product having Nicotinamide Riboside Chloride 250mg.
here is a probiotic connection to NR, where the author states “probiotic supplementation with Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 increased the nicotinamide production”,
“Yeast NAD+ Boosts Cognition, Endurance, Longevity”
my next Amazon order will be,
“TRU NIAGEN – The world’s most advanced NAD+ booster 250mg Per Serving (60 capsules/125mg)”
“Pterostilbene 100mg Capsules (Third Party Tested) Made in the USA, 60 Capsules by Double Wood Supplements ”
note: Amazon reviewers for this Pterostilbene product report “focus”, “brighter complexion, less pain in my joints and body, more energy and clarity of mind”, and “greater mental clarity”
ALTERNATIVE NAD+ SOURCES:
at this time most folks know of Nicotinamide Riboside (NR) from marketing, thanks to it’s patent such as in the product Basis by Elysium Health. although NR ingested is converted to Nicotinamide Mononucleotide (NMN) and NMN is converted to the desired co-enzyme Nicotinamide Adenine Dinucleotide (NAD+). NR is patented and is not found in blood serum. NMN is not patented is found in blood serum.
there was a patent battle in 2017 over the production of Nicotinamide Riboside described here,
“So, why is Basis and Nicotinamide Riboside more well known than NMN? The fact it is PATENTED, which allows for huge profit margins that can be plowed into advertising.”
i’m tempted to purchase the lower cost non-patented NAD+ precursor Nicotinamide Mononucleotide (NMN). although, i’ve opted to purchase TRU Niagen 250mg Nicotinamide Riboside because of this review:
By Larry on March 19, 2018
“The mice study that is referenced showed 300mg/kg NMN only increased NAD+ in liver and muscles by 14% for a few hours. This pales compared to a similar study on mice that showed 185mg/kg Nicotinamide Riboside increases 100% for much longer time.”
“Finally, niacin can be converted to NAD, but this, again, involves an inefficient metabolic pathway and taking large doses causes uncomfortable side effects.”
“NMN 250mg Serving Nicotinamide Mononucleotide Direct NAD+ Supplement, Anti Aging DNA Repair & Healthy Metabolism (2x 125mg Capsules 60ct).”
as an alternative to products explicitly labeled NMN or NR, i’m left to wonder if this Niacinamide product has NMN or NR in a significant percent. in reviews, folks are reporting less anxiety, depression, smooth skin, and as a sleep aid to be taken by evening only.
this is one cautionary note to avoid taking too much Niacinamide,
“For example, it is well known that NAD can be produced from L-tryptophan (an amino acid found in many foods), but this is an inefficient and unreliable process; the amino acid is likely to be utilized for other functions in the body. Nicotinamide can also be converted to NAD, but too much can inhibit certain critical processes.”
“NOW Niacinamide 500mg,100 Capsules”