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Category Archives: bioavailability
two age-reverse and nootropic pills
general info on a new science of an age-reverse to youth and nootropics
thought to share a summary of the science of combining two supplements for age-reverse and nootropics that has emerged the past year. you can search for “Nicotinamide Riboside” and “Pterostilbene” to find a plethora of science based articles. i will be testing both soon.
here is a general introduction to NAD+,
and a general science intro,
https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/
Pterostilbene
typically compared to resveratrol, for oral ingestion resveratrol has a 20% bioavailability whereas pterostilbene is near 80% at doses of 56-168mg/kg.
https://examine.com/supplements/pterostilbene/
Nicotinamide Riboside
TRU Niagen is made by ChromaDex and is FDA approved is a well reviewed product having Nicotinamide Riboside Chloride 250mg.
here is a probiotic connection to NR, where the author states “probiotic supplementation with Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 increased the nicotinamide production”,
“Yeast NAD+ Boosts Cognition, Endurance, Longevity”
https://www.realnatural.org/probiotic-yeasts-stimulate-nad-increase-metabolism-longevity/
my next Amazon order will be,
“TRU NIAGEN – The world’s most advanced NAD+ booster 250mg Per Serving (60 capsules/125mg)”
“Pterostilbene 100mg Capsules (Third Party Tested) Made in the USA, 60 Capsules by Double Wood Supplements ”
note: Amazon reviewers for this Pterostilbene product report “focus”, “brighter complexion, less pain in my joints and body, more energy and clarity of mind”, and “greater mental clarity”
ALTERNATIVE NAD+ SOURCES:
Nicotinamide Mononucleotide
at this time most folks know of Nicotinamide Riboside (NR) from marketing, thanks to it’s patent such as in the product Basis by Elysium Health. although NR ingested is converted to Nicotinamide Mononucleotide (NMN) and NMN is converted to the desired co-enzyme Nicotinamide Adenine Dinucleotide (NAD+). NR is patented and is not found in blood serum. NMN is not patented is found in blood serum.
there was a patent battle in 2017 over the production of Nicotinamide Riboside described here,
“So, why is Basis and Nicotinamide Riboside more well known than NMN? The fact it is PATENTED, which allows for huge profit margins that can be plowed into advertising.”
http://alivebynature.com/basis-niagen-by-elysium-health/
i’m tempted to purchase the lower cost non-patented NAD+ precursor Nicotinamide Mononucleotide (NMN). although, i’ve opted to purchase TRU Niagen 250mg Nicotinamide Riboside because of this review:
By Larry on March 19, 2018
“The mice study that is referenced showed 300mg/kg NMN only increased NAD+ in liver and muscles by 14% for a few hours. This pales compared to a similar study on mice that showed 185mg/kg Nicotinamide Riboside increases 100% for much longer time.”
“Finally, niacin can be converted to NAD, but this, again, involves an inefficient metabolic pathway and taking large doses causes uncomfortable side effects.”
“NMN 250mg Serving Nicotinamide Mononucleotide Direct NAD+ Supplement, Anti Aging DNA Repair & Healthy Metabolism (2x 125mg Capsules 60ct).”
http://a.co/dlAFKG0
as an alternative to products explicitly labeled NMN or NR, i’m left to wonder if this Niacinamide product has NMN or NR in a significant percent. in reviews, folks are reporting less anxiety, depression, smooth skin, and as a sleep aid to be taken by evening only.
this is one cautionary note to avoid taking too much Niacinamide,
https://www.needs.com/product/NDNL-1408-01
“For example, it is well known that NAD can be produced from L-tryptophan (an amino acid found in many foods), but this is an inefficient and unreliable process; the amino acid is likely to be utilized for other functions in the body. Nicotinamide can also be converted to NAD, but too much can inhibit certain critical processes.”
“NOW Niacinamide 500mg,100 Capsules”
http://a.co/6xGp18D
a sprout, avocado, spirulina, kelp, and turmeric brain sauce dish washed with Rooibos and choline
this is a picture of my typical lunch these days before mixing it into a mesh. it is way filling and the brain boost is amazing. upon hearing that phosphatidylcholine increased curcumin bioavailability, i started to washed down my turmeric dish with a glass of water having a mixed tablespoon of TWINLAB Choline Cocktail containing 375mg choline dihydrogen citrate. the flavors were definitely not complementary. i accidentally discovered a flavorful mix by adding a choline teaspoon to a Rooibos tea sitting about. the powder contents of an Alpha GPC having 300mg of L-alpha glycerylphosphorylcholine.
regarding food as medicine, using a small amount of coconut oil, i cook up tofu which contains phosphatidylcholine and heat the turmeric brain sauce to activate the turmeric although the quercetin in the white onions and capers are diminished in quality so first toast the tofu cubes then add the turmeric brain sauce and lower the heat to the lowest stove level. for me as a male, this is an occasional once a week meal to avoid an estrogen increase.
the fatty oils in avocado help to increase turmeric bioavailability. spiralina and kelp came just for the ride. you can see how to grow lentil sprouts from a few of my other blog posts.
here is a quote from one research paper,
“Male Wistar rats received 340 mg/kg of either unformulated curcumin or curcumin formulated with phosphatidylcholine (Meriva) by oral gavage. Curcumin, the accompanying curcuminoids desmethoxycurcumin and bisdesmethoxycurcumin, and the metabolites tetrahydrocurcumin, hexahydrocurcumin, curcumin glucuronide, and curcumin sulfate were identified in plasma, intestinal mucosa, and liver of rats which had received Meriva. Peak plasma levels for parent curcumin after administration of Meriva were 5-fold higher than the equivalent values seen after unformulated curcumin dosing. Similarly, liver levels of curcumin were higher after administration of Meriva as compared to unformulated curcumin. In contrast, curcumin concentrations in the gastrointestinal mucosa after ingestion of Meriva were somewhat lower than those observed after administration of unformulated curcumin.39 These results suggest that curcumin formulated with phosphatidylcholine furnishes higher systemic levels of parent agent than unformulated curcumin. In an attempt to increase the aqueous solubility of hydrophobic drugs, Letchford et al., showed a 13 × 10 5 fold increase in curcumin solubility in a polymeric micellar formulation containing methoxy poly (ethylene glycol)-block-polycaprolactone diblock copolymers (MePEG-b-PCL).71”
you can find the curcumin and choline link at, “Bioavailability of Curcumin: Problems and Promises”
